Phosphate starvation promotes swarming motility and cytotoxicity of Pseudomonas aeruginosa.
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ABSTRACT:
SUBMITTER: Bains M
PROVIDER: S-EPMC3426718 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
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Phosphate starvation promotes swarming motility and cytotoxicity of Pseudomonas aeruginosa.
Bains Manjeet M Fernández Lucía L Hancock Robert E W RE
Applied and environmental microbiology 20120706 18
We investigated the transcriptional responses of Pseudomonas aeruginosa under phosphate-deficient (0.2 mM) conditions compared to phosphate sufficiency (1 mM). This elicited enormous transcriptional changes in genes related to phosphate acquisition, quorum sensing, chemotaxis, toxin secretion, and regulation. This dysregulation also led to increased virulence-associated phenotypes, including swarming motility and cytotoxicity. ...[more]
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