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General one-pot, two-step protocol accessing a range of novel polycyclic heterocycles with high skeletal diversity.

ABSTRACT: An Ugi one-pot three-component four-center reaction was coupled with a subsequent acid mediated cyclodehydration step to furnish a multitude of unique scaffolds having in common an embedded or attached benzimidazole and often a ring system formed through lactamization. Using combinations of tethered Ugi inputs typically via tethered acid-ketone inputs and supporting reagents containing masked internal nucleophiles, such scaffolds were produced in good to excellent yields in an operationally friendly manner.

SUBMITTER: Xu Z

PROVIDER: S-EPMC3426865 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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General one-pot, two-step protocol accessing a range of novel polycyclic heterocycles with high skeletal diversity.

Xu Zhigang Z Ayaz Muhammad M Cappelli Alexandra A AA Hulme Christopher C

ACS combinatorial science 20120712 8

An Ugi one-pot three-component four-center reaction was coupled with a subsequent acid mediated cyclodehydration step to furnish a multitude of unique scaffolds having in common an embedded or attached benzimidazole and often a ring system formed through lactamization. Using combinations of tethered Ugi inputs typically via tethered acid-ketone inputs and supporting reagents containing masked internal nucleophiles, such scaffolds were produced in good to excellent yields in an operationally frie ...[more]

PMID: 22746181

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