Ontology highlight
ABSTRACT:
SUBMITTER: Marzano V
PROVIDER: S-EPMC3426930 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Marzano Valeria V Santini Simonetta S Rossi Claudia C Zucchelli Mirco M D'Alessandro Annamaria A Marchetti Carlo C Mingardi Michele M Stagni Venturina V Barilà Daniela D Urbani Andrea A
Journal of proteomics 20120526 15
Ataxia Telangiectasia Mutated (ATM) protein kinase is a key effector in the modulation of the functionality of some important stress responses, including DNA damage and oxidative stress response, and its deficiency is the hallmark of Ataxia Telangiectasia (A-T), a rare genetic disorder. ATM modulates the activity of hundreds of target proteins, essential for the correct balance between proliferation and cell death. The aim of this study is to evaluate the phenotypic adaptation at the protein lev ...[more]