Ontology highlight
ABSTRACT:
SUBMITTER: Goddard AF
PROVIDER: S-EPMC3427132 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Goddard Amanda F AF Staudinger Benjamin J BJ Dowd Scot E SE Joshi-Datar Amruta A Wolcott Randall D RD Aitken Moira L ML Fligner Corinne L CL Singh Pradeep K PK
Proceedings of the National Academy of Sciences of the United States of America 20120807 34
Recent work using culture-independent methods suggests that the lungs of cystic fibrosis (CF) patients harbor a vast array of bacteria not conventionally implicated in CF lung disease. However, sampling lung secretions in living subjects requires that expectorated specimens or collection devices pass through the oropharynx. Thus, contamination could confound results. Here, we compared culture-independent analyses of throat and sputum specimens to samples directly obtained from the lungs at the t ...[more]