Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight.
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ABSTRACT:
SUBMITTER: Mulligan CJ
PROVIDER: S-EPMC3427280 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
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Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight.
Mulligan Connie J CJ D'Errico Nicole C NC Stees Jared J Hughes David A DA
Epigenetics 20120719 8
Early life experiences, including those in utero, have been linked to increased risk for adult-onset chronic disease. The underlying assumption is that there is a critical period of developmental plasticity in utero when selection of the fetal phenotype that is best adapted to the intrauterine environment occurs. The current study is the first to test the idea that extreme maternal psychosocial stressors, as observed in the Democratic Republic of Congo, may modify locus-specific epigenetic marks ...[more]
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