Ontology highlight
ABSTRACT:
SUBMITTER: Boink GJ
PROVIDER: S-EPMC3427660 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Boink Gerard J J GJ Lu Jia J Driessen Helen E HE Duan Lian L Sosunov Eugene A EA Anyukhovsky Evgeny P EP Shlapakova Iryna N IN Lau David H DH Rosen Tove S TS Danilo Peter P Jia Zhiheng Z Ozgen Nazira N Bobkov Yevgeniy Y Guo Yuanjian Y Brink Peter R PR Kryukova Yelena Y Robinson Richard B RB Entcheva Emilia E Cohen Ira S IS Rosen Michael R MR
Circulation. Arrhythmia and electrophysiology 20120621 4
<h4>Background</h4>In depolarized myocardial infarct epicardial border zones, the cardiac sodium channel is largely inactivated, contributing to slow conduction and reentry. We have demonstrated that adenoviral delivery of the skeletal muscle Na(+) channel (SkM1) to epicardial border zones normalizes conduction and reduces induction of ventricular tachycardia/ventricular fibrillation. We now studied the impact of canine mesenchymal stem cells (cMSCs) in delivering SkM1.<h4>Methods and results</h ...[more]