Ontology highlight
ABSTRACT:
SUBMITTER: Bouladoux N
PROVIDER: S-EPMC3427718 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Bouladoux N N Hall J A JA Grainger J R JR dos Santos L M LM Kann M G MG Nagarajan V V Verthelyi D D Belkaid Y Y
Mucosal immunology 20120523 6
The microbiota contributes to the induction of both effector and regulatory responses in the gastrointestinal (GI) tract. However, the mechanisms controlling these distinct properties remain poorly understood. We previously showed that commensal DNA promotes intestinal immunity. Here, we find that the capacity of bacterial DNA to stimulate immune responses is species specific and correlated with the frequency of motifs known to exert immunosuppressive function. In particular, we show that the DN ...[more]