Ontology highlight
ABSTRACT:
SUBMITTER: Kong X
PROVIDER: S-EPMC3427755 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Kong Xiangqian X Qin Jie J Li Zeng Z Vultur Adina A Tong Linjiang L Feng Enguang E Rajan Geena G Liu Shien S Lu Junyan J Liang Zhongjie Z Zheng Mingyue M Zhu Weiliang W Jiang Hualiang H Herlyn Meenhard M Liu Hong H Marmorstein Ronen R Luo Cheng C
Organic & biomolecular chemistry 20120901 36
Oncogenic mutations in critical nodes of cellular signaling pathways have been associated with tumorigenesis and progression. The B-Raf protein kinase, a key hub in the canonical MAPK signaling cascade, is mutated in a broad range of human cancers and especially in malignant melanoma. The most prevalent B-Raf(V600E) mutant exhibits elevated kinase activity and results in constitutive activation of the MAPK pathway, thus making it a promising drug target for cancer therapy. Herein, we describe th ...[more]