Ontology highlight
ABSTRACT:
SUBMITTER: Korn T
PROVIDER: S-EPMC3427780 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Korn Thomas T Reddy Jayagopala J Gao Wenda W Bettelli Estelle E Awasthi Amit A Petersen Troels R TR Bäckström B Thomas BT Sobel Raymond A RA Wucherpfennig Kai W KW Strom Terry B TB Oukka Mohamed M Kuchroo Vijay K VK
Nature medicine 20070325 4
Treatment with ex vivo-generated regulatory T cells (T-reg) has been regarded as a potentially attractive therapeutic approach for autoimmune diseases. However, the dynamics and function of T-reg in autoimmunity are not well understood. Thus, we developed Foxp3gfp knock-in (Foxp3gfp.KI) mice and myelin oligodendrocyte glycoprotein (MOG)(35-55)/IA(b) (MHC class II) tetramers to track autoantigen-specific effector T cells (T-eff) and T-reg in vivo during experimental autoimmune encephalomyelitis ( ...[more]