Ontology highlight
ABSTRACT:
SUBMITTER: Somm E
PROVIDER: S-EPMC3428092 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Somm Emmanuel E Bonnet Nicolas N Martinez Alberto A Marks Philip M H PM Cadd Verity A VA Elliott Mark M Toulotte Audrey A Ferrari Serge L SL Rizzoli René R Hüppi Petra S PS Harper Elaine E Melmed Shlomo S Jones Richard R Aubert Michel L ML
The Journal of clinical investigation 20120801 9
Botulinum neurotoxins (BoNTs) are zinc endopeptidases that block release of the neurotransmitter acetylcholine in neuromuscular synapses through cleavage of soluble N-ethylmaleimide-sensitive fusion (NSF) attachment protein receptor (SNARE) proteins, which promote fusion of synaptic vesicles to the plasma membrane. We designed and tested a BoNT-derived targeted secretion inhibitor (TSI) targeting pituitary somatotroph cells to suppress growth hormone (GH) secretion and treat acromegaly. This rec ...[more]