Ontology highlight
ABSTRACT:
SUBMITTER: Ahn YH
PROVIDER: S-EPMC3428095 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Ahn Young-Ho YH Gibbons Don L DL Chakravarti Deepavali D Creighton Chad J CJ Rizvi Zain H ZH Adams Henry P HP Pertsemlidis Alexander A Gregory Philip A PA Wright Josephine A JA Goodall Gregory J GJ Flores Elsa R ER Kurie Jonathan M JM
The Journal of clinical investigation 20120801 9
Metastatic cancer is extremely difficult to treat, and the presence of metastases greatly reduces a cancer patient's likelihood of long-term survival. The ZEB1 transcriptional repressor promotes metastasis through downregulation of microRNAs (miRs) that are strong inducers of epithelial differentiation and inhibitors of stem cell factors. Given that each miR can target multiple genes with diverse functions, we posited that the prometastatic network controlled by ZEB1 extends beyond these process ...[more]