Ontology highlight
ABSTRACT:
SUBMITTER: Cipriani V
PROVIDER: S-EPMC3428154 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Cipriani Valentina V Leung Hin-Tak HT Plagnol Vincent V Bunce Catey C Khan Jane C JC Shahid Humma H Moore Anthony T AT Harding Simon P SP Bishop Paul N PN Hayward Caroline C Campbell Susan S Armbrecht Ana Maria AM Dhillon Baljean B Deary Ian J IJ Campbell Harry H Dunlop Malcolm M Dominiczak Anna F AF Mann Samantha S SS Jenkins Sharon A SA Webster Andrew R AR Bird Alan C AC Lathrop Mark M Zelenika Diana D Souied Eric H EH Sahel José-Alain JA Léveillard Thierry T Cree Angela J AJ Gibson Jane J Ennis Sarah S Lotery Andrew J AJ Wright Alan F AF Clayton David G DG Yates John R W JR
Human molecular genetics 20120613 18
Age-related macular degeneration (AMD) is a leading cause of visual loss in Western populations. Susceptibility is influenced by age, environmental and genetic factors. Known genetic risk loci do not account for all the heritability. We therefore carried out a genome-wide association study of AMD in the UK population with 893 cases of advanced AMD and 2199 controls. This showed an association with the well-established AMD risk loci ARMS2 (age-related maculopathy susceptibility 2)-HTRA1 (HtrA ser ...[more]