Dataset Information

Creation of an open-access, mutation-defined fibroblast resource for neurological disease research.

ABSTRACT: Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into neurons and glia. Access to patient cell lines carrying the relevant mutations is a limiting factor for many centres wishing to pursue this research. We have therefore generated an open-access collection of fibroblast lines from patients carrying mutations linked to neurological disease. These cell lines have been deposited in the National Institute for Neurological Disorders and Stroke (NINDS) Repository at the Coriell Institute for Medical Research and can be requested by any research group for use in in vitro disease modelling. There are currently 71 mutation-defined cell lines available for request from a wide range of neurological disorders and this collection will be continually expanded. This represents a significant resource that will advance the use of patient cells as disease models by the scientific community.

SUBMITTER: Wray S

PROVIDER: S-EPMC3428297 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Creation of an open-access, mutation-defined fibroblast resource for neurological disease research.

Wray Selina S Self Matthew M Lewis Patrick A PA Taanman Jan-Willem JW Ryan Natalie S NS Mahoney Colin J CJ Liang Yuying Y Devine Michael J MJ Sheerin Una-Marie UM Houlden Henry H Morris Huw R HR Healy Daniel D Marti-Masso Jose-Felix JF Preza Elisavet E Barker Suzanne S Sutherland Margaret M Corriveau Roderick A RA D'Andrea Michael M Schapira Anthony H V AH Uitti Ryan J RJ Guttman Mark M Opala Grzegorz G Jasinska-Myga Barbara B Puschmann Andreas A Nilsson Christer C Espay Alberto J AJ Slawek Jaroslaw J Gutmann Ludwig L Boeve Bradley F BF Boylan Kevin K Stoessl A Jon AJ Ross Owen A OA Maragakis Nicholas J NJ Van Gerpen Jay J Gerstenhaber Melissa M Gwinn Katrina K Dawson Ted M TM Isacson Ole O Marder Karen S KS Clark Lorraine N LN Przedborski Serge E SE Finkbeiner Steven S Rothstein Jeffrey D JD Wszolek Zbigniew K ZK Rossor Martin N MN Hardy John J

PloS one 20120827 8

Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into ne ...[more]

PMID: 22952635

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Dataset Information

Creation of an open-access, mutation-defined fibroblast resource for neurological disease research.

Publications

Creation of an open-access, mutation-defined fibroblast resource for neurological disease research.

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