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Translational selection of genes coding for perfectly conserved proteins among three mosquito vectors.

ABSTRACT: The biased usage of synonymous codons affects translational efficiency of genes. We studied codon usage patterns of genes that are perfectly conserved at the amino acid level among three important mosquito vector species: Aedes aegypti (vector of dengue virus), Anopheles gambiae (vector of malaria) and Culex quinquefasciatus (vector of lymphatic filariasis and West Nile Virus). Although these proteins have the same amino acid sequences, non-random usage of synonymous codons is evident among the orthologous genes. The coding sequences of these genes were simulated to generate random mutation sites to be further investigated for patterns of codon bias. It was found that codon usage bias is significantly higher in genes that represented perfectly conserved proteins than genes where variation was apparent at the amino acid sequence. Our results suggest that genes coding for perfectly conserved proteins are highly biased with optimized codons and may be under stringent translational selection in these vector species.

SUBMITTER: Rodriguez O

PROVIDER: S-EPMC3428495 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Translational selection of genes coding for perfectly conserved proteins among three mosquito vectors.

Rodriguez Olaf O Singh Brajendra K BK Severson David W DW Behura Susanta K SK Behura Susanta K SK

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20120615 7

The biased usage of synonymous codons affects translational efficiency of genes. We studied codon usage patterns of genes that are perfectly conserved at the amino acid level among three important mosquito vector species: Aedes aegypti (vector of dengue virus), Anopheles gambiae (vector of malaria) and Culex quinquefasciatus (vector of lymphatic filariasis and West Nile Virus). Although these proteins have the same amino acid sequences, non-random usage of synonymous codons is evident among the ...[more]

PMID: 22705463

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Translational selection of genes coding for perfectly conserved proteins among three mosquito vectors.

Publications

Translational selection of genes coding for perfectly conserved proteins among three mosquito vectors.

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