Ontology highlight
ABSTRACT:
SUBMITTER: Chang EY
PROVIDER: S-EPMC3428728 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Chang Evelyn Y EY Ferreira Helder H Somers Joanna J Nusinow Dmitri A DA Owen-Hughes Tom T Narlikar Geeta J GJ
Biochemistry 20081201 51
The variant histone macroH2A helps maintain X inactivation and gene silencing. Previous work implied that nucleosomes containing macroH2A cannot be remodeled by ISWI and SWI/SNF chromatin remodeling enzymes. Using approaches that prevent misassembly of macroH2A nucleosomes, we find that macroH2A nucleosomes are excellent substrates for both enzyme families. Interestingly, SWI/SNF, which is involved in gene activation, preferentially binds H2A nucleosomes over macroH2A nucleosomes, but ACF, an IS ...[more]