Ontology highlight
ABSTRACT:
SUBMITTER: Pilli M
PROVIDER: S-EPMC3428731 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Immunity 20120801 2
Autophagy is a fundamental biological process of the eukaryotic cell contributing to diverse cellular and physiological functions including cell-autonomous defense against intracellular pathogens. Here, we screened the Rab family of membrane trafficking regulators for effects on autophagic elimination of Mycobacterium tuberculosis var. bovis BCG and found that Rab8b and its downstream interacting partner, innate immunity regulator TBK-1, are required for autophagic elimination of mycobacteria in ...[more]