Ontology highlight
ABSTRACT:
SUBMITTER: Homer H
PROVIDER: S-EPMC3428834 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Homer Hayden H Gui Liming L Carroll John J
Science (New York, N.Y.) 20091101 5955
Two critical stages of mammalian oocyte regulation are prophase I arrest, which is important for sustaining the oocyte pool, and the progression through meiosis I (MI) to produce fertilizable eggs. We have found that the spindle assembly checkpoint protein BubR1 regulates both stages in mouse oocytes. We show that oocytes depleted of BubR1 cannot sustain prophase I arrest and readily undergo germinal vesicle breakdown, a marker for reentry into MI. BubR1-depleted oocytes then arrest before compl ...[more]