Unknown

Dataset Information

0

Childhood body mass index and adult pro-inflammatory and pro-thrombotic risk factors: data from the New Delhi birth cohort.


ABSTRACT: OBJECTIVE:Weight gain and growth in early life may influence adult pro-inflammatory and pro-thrombotic cardiovascular risk factors. METHODS:Follow-up of a birth cohort in New Delhi, India, whose weight and height were measured every 6 months until age 21 years. Body mass index (BMI) at birth, during infancy (2 years), childhood (11 years) and adulthood (26-32 years) and BMI gain between these ages were analysed in 886 men and 640 women with respect to adult fibrinogen, high-sensitivity C-reactive protein (hsCRP) and plasminogen activator inhibitor-1 (PAI-1) concentrations. RESULTS:All the pro-inflammatory/pro-thrombotic risk factors were higher in participants with higher adiposity. In women, BMI at birth and age 2 years was inversely related to fibrinogen (P?=?0.002 and 0.05) and, after adjusting for adult adiposity, to hsCRP (P?=?0.02 and 0.009). After adjusting for adult adiposity, BMI at 2 years was inversely related to hsCRP and PAI-1 concentrations (P?

SUBMITTER: Lakshmy R 

PROVIDER: S-EPMC3428891 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Childhood body mass index and adult pro-inflammatory and pro-thrombotic risk factors: data from the New Delhi birth cohort.

Lakshmy Ramakrishnan R   Fall Caroline Hd CH   Sachdev Harshpal Singh HS   Osmond Clive C   Prabhakaran Dorairaj D   Biswas Sushant Dey SD   Tandon Nikhil N   Ramji Siddharth S   Reddy Kolli Srinath KS   Barker David Jp DJ   Bhargava Santosh K SK  

International journal of epidemiology 20100726 1


<h4>Objective</h4>Weight gain and growth in early life may influence adult pro-inflammatory and pro-thrombotic cardiovascular risk factors.<h4>Methods</h4>Follow-up of a birth cohort in New Delhi, India, whose weight and height were measured every 6 months until age 21 years. Body mass index (BMI) at birth, during infancy (2 years), childhood (11 years) and adulthood (26-32 years) and BMI gain between these ages were analysed in 886 men and 640 women with respect to adult fibrinogen, high-sensit  ...[more]

Similar Datasets

| S-EPMC3035100 | biostudies-other
| S-EPMC5710582 | biostudies-literature
| S-EPMC5788457 | biostudies-literature
| S-EPMC3769639 | biostudies-literature
| S-EPMC7905846 | biostudies-literature
| S-EPMC4090733 | biostudies-literature
| S-EPMC5860555 | biostudies-other
| S-EPMC7191432 | biostudies-literature
| S-EPMC9830482 | biostudies-literature
| S-EPMC7581004 | biostudies-literature