Ontology highlight
ABSTRACT:
SUBMITTER: Prahlad V
PROVIDER: S-EPMC3429343 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20080501 5877
Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we show that within the metazoan Caenorhabditis elegans, the heat shock response of somat ...[more]