Ontology highlight
ABSTRACT:
SUBMITTER: Zhan H
PROVIDER: S-EPMC3429469 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20120828 8
It is widely believed that both common and rare variants contribute to the risks of common diseases or complex traits and the cumulative effects of multiple rare variants can explain a significant proportion of trait variances. Advances in high-throughput DNA sequencing technologies allow us to genotype rare causal variants and investigate the effects of such rare variants on complex traits. We developed an adaptive ridge regression method to analyze the collective effects of multiple variants i ...[more]