Ontology highlight
ABSTRACT:
SUBMITTER: Shukla NM
PROVIDER: S-EPMC3429503 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Shukla Nikunj M NM Salunke Deepak B DB Balakrishna Rajalakshmi R Mutz Cole A CA Malladi Subbalakshmi S SS David Sunil A SA
PloS one 20120828 8
Engagement of toll-like receptors (TLRs) serve to link innate immune responses with adaptive immunity and can be exploited as powerful vaccine adjuvants for eliciting both primary and anamnestic immune responses. TLR7 agonists are highly immunostimulatory without inducing dominant proinflammatory cytokine responses. We synthesized a dendrimeric molecule bearing six units of a potent TLR7/TLR8 dual-agonistic imidazoquinoline to explore if multimerization of TLR7/8 would result in altered activity ...[more]