Ontology highlight
ABSTRACT:
SUBMITTER: Tang B
PROVIDER: S-EPMC3429542 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Tang Bin B Li Na N Gu Jiang J Zhuang Yuan Y Li Qian Q Wang Hai-Guang HG Fang Yao Y Yu Bo B Zhang Jin-Yu JY Xie Qing-Hua QH Chen Li L Jiang Xue-Jun XJ Xiao Bin B Zou Quan-Ming QM Mao Xu-Hu XH
Autophagy 20120531 7
Helicobacter pylori evade immune responses and achieve persistent colonization in the stomach. However, the mechanism by which H. pylori infections persist is not clear. In this study, we showed that MIR30B is upregulated during H. pylori infection of an AGS cell line and human gastric tissues. Upregulation of MIR30B benefited bacterial replication by compromising the process of autophagy during the H. pylori infection. As a potential mechanistic explanation for this observation, we demonstrate ...[more]