Ontology highlight
ABSTRACT:
SUBMITTER: Rogelj B
PROVIDER: S-EPMC3429604 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Scientific reports 20120828
Fused in sarcoma (FUS) and TAR DNA-binding protein 43 (TDP-43) are RNA-binding proteins pathogenetically linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), but it is not known if they regulate the same transcripts. We addressed this question using crosslinking and immunoprecipitation (iCLIP) in mouse brain, which showed that FUS binds along the whole length of the nascent RNA with limited sequence specificity to GGU and related motifs. A saw-tooth binding ...[more]