Ontology highlight
ABSTRACT:
SUBMITTER: Zhao B
PROVIDER: S-EPMC3430247 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20120601 7
Coelibactin is a putative non-ribosomally synthesized peptide with predicted zincophore activity and which has been implicated in antibiotic regulation in Streptomyces coelicolor A3(2). The coelibactin biosynthetic pathway contains a stereo- and regio-specific monooxygenation step catalyzed by a cytochrome P450 enzyme (CYP105N1). We have determined the X-ray crystal structure of CYP105N1 at 2.9 Å and analyzed it in the context of the bacterial CYP105 family as a whole. The crystal structure reve ...[more]