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Non-lytic expulsion/exocytosis of Candida albicans from macrophages.

ABSTRACT: Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and viable. Partial engulfment of hyphal C. albicans without macrophage lysis is also demonstrated. These observations underpin the complexity of interactions between C. albicans and innate immune cells.

SUBMITTER: Bain JM 

PROVIDER: S-EPMC3430864 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Non-lytic expulsion/exocytosis of Candida albicans from macrophages.

Bain Judith M JM   Lewis Leanne E LE   Okai Blessing B   Quinn Janet J   Gow Neil A R NA   Erwig Lars-Peter LP  

Fungal genetics and biology : FG & B 20120204 9

Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and viable. Partial engulfment of hyphal C. albicans without macrophage lysis is also demonstrated. These observations underpin the complexity of interactions between C. albicans and innate immune cells. ...[more]

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