Ontology highlight
ABSTRACT:
SUBMITTER: Malinauskas T
PROVIDER: S-EPMC3430870 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Malinauskas Tomas T Aricescu A Radu AR Lu Weixian W Siebold Christian C Jones E Yvonne EY
Nature structural & molecular biology 20110710 8
Wnt morphogens control embryonic development and homeostasis in adult tissues. In vertebrates the N-terminal WIF domain (WIF-1(WD)) of Wnt inhibitory factor 1 (WIF-1) binds Wnt ligands. Our crystal structure of WIF-1(WD) reveals a previously unidentified binding site for phospholipid; two acyl chains extend deep into the domain, and the head group is exposed to the surface. Biophysical and cellular assays indicate that there is a WIF-1(WD) Wnt-binding surface proximal to the lipid head group but ...[more]