Ontology highlight
ABSTRACT:
SUBMITTER: Walker A
PROVIDER: S-EPMC3430968 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Walker Andrea A Su Hua H Conti Mary Anne MA Harb Nicole N Adelstein Robert S RS Sato Noboru N
Nature communications 20100907
Human pluripotent stem (hPS) cells such as human embryonic stem (hES) and induced pluripotent stem (hiPS) cells are vulnerable under single cell conditions, which hampers practical applications; yet, the mechanisms underlying this cell death remain elusive. In this paper, we demonstrate that treatment with a specific inhibitor of non-muscle myosin II (NMII), blebbistatin, enhances the survival of hPS cells under clonal density and suspension conditions, and, in combination with a synthetic matri ...[more]