Ontology highlight
ABSTRACT:
SUBMITTER: Walker A
PROVIDER: S-EPMC3430968 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Nature communications 20100907
Human pluripotent stem (hPS) cells such as human embryonic stem (hES) and induced pluripotent stem (hiPS) cells are vulnerable under single cell conditions, which hampers practical applications; yet, the mechanisms underlying this cell death remain elusive. In this paper, we demonstrate that treatment with a specific inhibitor of non-muscle myosin II (NMII), blebbistatin, enhances the survival of hPS cells under clonal density and suspension conditions, and, in combination with a synthetic matri ...[more]