Ontology highlight
ABSTRACT:
SUBMITTER: Gagliardi PA
PROVIDER: S-EPMC3431179 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Gagliardi Paolo Armando PA di Blasio Laura L Orso Francesca F Seano Giorgio G Sessa Roberto R Taverna Daniela D Bussolino Federico F Primo Luca L
Neoplasia (New York, N.Y.) 20120801 8
3-phosphoinositide-dependent protein kinase 1 (PDK1) is the pivotal element of the phosphatidylinositol 3 kinase (PI3K) signaling pathway because it phosphorylates Akt/PKB through interactions with phosphatidylinositol 3,4,5 phosphate. Recent data indicate that PDK1 is overexpressed in many breast carcinomas and that alterations of PDK1 are critical in the context of oncogenic PI3K activation. However, the role of PDK1 in tumor progression is still controversial. Here, we show that PDK1 is requi ...[more]