Genome patterns of selection and introgression of haplotypes in natural populations of the house mouse (Mus musculus).

ABSTRACT: General parameters of selection, such as the frequency and strength of positive selection in natural populations or the role of introgression, are still insufficiently understood. The house mouse (Mus musculus) is a particularly well-suited model system to approach such questions, since it has a defined history of splits into subspecies and populations and since extensive genome information is available. We have used high-density single-nucleotide polymorphism (SNP) typing arrays to assess genomic patterns of positive selection and introgression of alleles in two natural populations of each of the subspecies M. m. domesticus and M. m. musculus. Applying different statistical procedures, we find a large number of regions subject to apparent selective sweeps, indicating frequent positive sel

SUBMITTER: Staubach F 

PROVIDER: S-EPMC3431316 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature