Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC3431561 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Cancer cell 20091201 6
We discovered a high-level amplicon involving the chr19q13.41 microRNA (miRNA) cluster (C19MC) in 11/45 ( approximately 25%) primary CNS-PNET, which results in striking overexpression of miR-517c and 520g. Constitutive expression of miR-517c or 520g promotes in vitro and in vivo oncogenicity, modulates cell survival, and robustly enhances growth of untransformed human neural stem cells (hNSCs) in part by upregulating WNT pathway signaling and restricting differentiation of hNSCs. Remarkably, the ...[more]