Ontology highlight
ABSTRACT:
SUBMITTER: Bolderson E
PROVIDER: S-EPMC3431694 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20120618 33
The DNA damage response encompasses a complex series of signaling pathways that function to regulate and facilitate the repair of damaged DNA. Recent studies have shown that the repair of transcriptionally inactive chromatin, named heterochromatin, is dependent upon the phosphorylation of the co-repressor, Krüppel-associated box (KRAB) domain-associated protein (KAP-1), by the ataxia telangiectasia-mutated (ATM) kinase. Co-repressors, such as KAP-1, function to regulate the rigid structure of he ...[more]