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A novel function of p53: a gatekeeper of retinal detachment.

ABSTRACT: Proliferative vitreoretinopathy (PVR) is a blinding disease associated with rhegmatogenous retinal detachment, for which there is no satisfactory treatment. Surgery helps in many cases, but, to our knowledge, there are no pharmacological approaches to reduce PVR risk. We report that suppressing expression of p53 was a required event in two assays of PVR (namely, platelet-derived growth factor receptor ?-mediated contraction of cells in a collagen gel and retinal detachment in an animal model of PVR). Furthermore, preventing the decline in the level of p53 with agents such as Nutlin-3 protected from retinal detachment, which is the most vision-compromising component of PVR. Finally, Nutlin-3 may be effective in the clinical setting because it prevented human PVR vitreous-induced contraction of cells isolated from a patient PVR membrane. These studies identify Nutlin-3 as a potential PVR prophylaxis.

SUBMITTER: Lei H

PROVIDER: S-EPMC3432438 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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A novel function of p53: a gatekeeper of retinal detachment.

Lei Hetian H Rheaume Marc-Andre MA Cui Jing J Mukai Shizuo S Maberley David D Samad Arif A Matsubara Joanne J Kazlauskas Andrius A

The American journal of pathology 20120901 3

Proliferative vitreoretinopathy (PVR) is a blinding disease associated with rhegmatogenous retinal detachment, for which there is no satisfactory treatment. Surgery helps in many cases, but, to our knowledge, there are no pharmacological approaches to reduce PVR risk. We report that suppressing expression of p53 was a required event in two assays of PVR (namely, platelet-derived growth factor receptor α-mediated contraction of cells in a collagen gel and retinal detachment in an animal model of ...[more]

PMID: 22901751

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Biomarkers for PVR in rhegmatogenous retinal detachment.

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| S-EPMC6447182 | biostudies-literature

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| S-EPMC7725826 | biostudies-literature

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