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Functional significance of striatal responses during episodic decisions: recovery or goal attainment?

ABSTRACT: Memory retrieval is typically a goal-directed behavior, and as such, potentially influenced by reinforcement and motivation processes. Although striatal activation is often evident during memory retrieval, its functional significance remains unclear because typical memory paradigms do not control the motivational significance of memory decisions. We used event-related functional magnetic resonance imaging (fMRI) to investigate striatal activation during recognition with and without performance-linked monetary incentives. During initial performance in the absence of incentives, dorsal striatal activation for "Old" memory conclusions nonetheless exceeded that for "New" conclusions regardless of the accuracy of these conclusions. In contrast, subsequent scans paired incentives with either "Old" or "New" conclusions and demonstrated greater activation for whichever judgment was potentially rewarded, both with and without performance feedback. The data demonstrate that striatal activation during recognition judgments does not signal monetary reward receipt, cognitive feedback, or successful episodic retrieval. Instead, it is heavily dependent upon satisfaction of the subjective goals of the observer.

SUBMITTER: Han S

PROVIDER: S-EPMC3433049 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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Functional significance of striatal responses during episodic decisions: recovery or goal attainment?

Han Sanghoon S Huettel Scott A SA Raposo Ana A Adcock R Alison RA Dobbins Ian G IG

The Journal of neuroscience : the official journal of the Society for Neuroscience 20100301 13

Memory retrieval is typically a goal-directed behavior, and as such, potentially influenced by reinforcement and motivation processes. Although striatal activation is often evident during memory retrieval, its functional significance remains unclear because typical memory paradigms do not control the motivational significance of memory decisions. We used event-related functional magnetic resonance imaging (fMRI) to investigate striatal activation during recognition with and without performance-l ...[more]

PMID: 20357127

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Project description:ObjectivesTo examine women's perceptions of endometriosis-associated disease burden and its impact on life decisions and goal attainment.DesignAn anonymous online survey was distributed in October 2018 through the social media network MyEndometriosisTeam.com.ParticipantsWomen aged 19 years and older living in several English-speaking countries who self-identified as having endometriosis.Outcome measuresPatients' perspectives on how endometriosis has affected their work, education, relationships, overall life decisions and attainment of goals. Subanalyses were performed for women who identified as 'less positive about the future' (LPAF) or had 'not reached their full potential' (NRFP) due to endometriosis.Results743 women completed the survey. Women reported high levels of pain when pain was at its worst (mean score, 8.9 on severity scale of 0 (no pain) to 10 (worst imaginable pain)) and most (56%, n=415) experienced pain daily. Women reported other negative experiences attributed to endometriosis, including emergency department visits (66%, n=485), multiple surgeries (55%, n=406) and prescription treatments for symptoms of endometriosis (72%, n=529). Women indicated that they believed endometriosis had a negative impact on their educational and professional achievements, social lives/relationships and overall physical health. Most women 'somewhat agreed'/'strongly agreed' that endometriosis caused them to lose time in life (81%, n=601), feel LPAF (80%, n=589) and feel they had NRFP (75%, n=556). Women who identified as LPAF or NRFP generally reported more negative experiences than those who were non-LPAF or non-NRFP.ConclusionsWomen who completed this survey reported pain and negative experiences related to endometriosis that were perceived to negatively impact major life-course decisions and attainment of goals. Greater practitioner awareness of the impact that endometriosis has on a woman's life course and the importance of meaningful dialogue with patients may be important for improving long-term management of the disease and help identify women who are most vulnerable.

Dataset Information

Functional significance of striatal responses during episodic decisions: recovery or goal attainment?

Publications

Functional significance of striatal responses during episodic decisions: recovery or goal attainment?

Similar Datasets

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