Ontology highlight
ABSTRACT:
SUBMITTER: Martinelli N
PROVIDER: S-EPMC3433253 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Martinelli Nicolas N Hartlieb Bettina B Usami Yoshiko Y Sabin Charles C Dordor Aurelien A Miguet Nolwenn N Avilov Sergiy V SV Ribeiro Euripedes A EA Göttlinger Heinrich H Weissenhorn Winfried W
Journal of molecular biology 20120308 1-2
Endosomal sorting complexes required for transport (ESCRTs) regulate diverse processes ranging from receptor sorting at endosomes to distinct steps in cell division and budding of some enveloped viruses. Common to all processes is the membrane recruitment of ESCRT-III that leads to membrane fission. Here, we show that CC2D1A is a novel regulator of ESCRT-III CHMP4B function. We demonstrate that CHMP4B interacts directly with CC2D1A and CC2D1B with nanomolar affinity by forming a 1:1 complex. Del ...[more]