Ontology highlight
ABSTRACT:
SUBMITTER: Lee CW
PROVIDER: S-EPMC3433393 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Lee Chi-Wai CW Wong Leo Lap-Yan LL Tse Edith Yuk-Ting EY Liu Heong-Fai HF Leong Veronica Yee-Law VY Lee Joyce Man-Fong JM Hardie D Grahame DG Ng Irene Oi-Lin IO Ching Yick-Pang YP
Cancer research 20120622 17
AMP-activated protein kinase (AMPK), a biologic sensor for cellular energy status, has been shown to act upstream and downstream of known tumor suppressors. However, whether AMPK itself plays a tumor suppressor role in cancer remains unclear. Here, we found that the α2 catalytic subunit isoform of AMPK is significantly downregulated in hepatocellular carcinoma (HCC). Clinicopathologic analysis revealed that underexpression of AMPK-α2 was statistically associated with an undifferentiated cellular ...[more]