Ontology highlight
ABSTRACT:
SUBMITTER: Lee HY
PROVIDER: S-EPMC3433402 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Lee Hye Young HY Ge Woo-Ping WP Huang Wendy W He Ye Y Wang Gordon X GX Rowson-Baldwin Ashley A Smith Stephen J SJ Jan Yuh Nung YN Jan Lily Yeh LY
Neuron 20111101 4
How transmitter receptors modulate neuronal signaling by regulating voltage-gated ion channel expression remains an open question. Here we report dendritic localization of mRNA of Kv4.2 voltage-gated potassium channel, which regulates synaptic plasticity, and its local translational regulation by fragile X mental retardation protein (FMRP) linked to fragile X syndrome (FXS), the most common heritable mental retardation. FMRP suppression of Kv4.2 is revealed by elevation of Kv4.2 in neurons from ...[more]