Ontology highlight
ABSTRACT:
SUBMITTER: Wheeler SE
PROVIDER: S-EPMC3433855 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Wheeler Sarah E SE Morariu Elena M EM Bednash Joseph S JS Otte Charlton G CG Seethala Raja R RR Chiosea Simion I SI Grandis Jennifer R JR
Clinical cancer research : an official journal of the American Association for Cancer Research 20120406 10
<h4>Purpose</h4>EGF receptor variant III (EGFRvIII) has been detected in several cancers in which tumors expressing this truncated growth factor receptor show more aggressive behavior. The molecular mechanisms that contribute to EGFRvIII-mediated tumor progression that are amenable to targeted therapy are incompletely understood. The present study aimed to better define the role of Src family kinases (SFKs) in EGFRvIII-mediated cell motility and tumor growth of head and neck squamous cell carcin ...[more]