Ontology highlight
ABSTRACT:
SUBMITTER: Le Bars H
PROVIDER: S-EPMC3434739 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Journal of bacteriology 20120701 13
In bacteria, normal mutation frequencies are mostly around 10(-10) per base pair. However, there exists natural isolates, called "mutators," that exhibit permanent mutation occurrences up to 1,000-fold greater than usual. As mutations play essential roles, particularly in the evolution of antibiotic resistance, bacteria showing elevated mutation rates could have an important responsibility in the emergence of antibiotic resistance, especially in the clinical background. In this announcement, we ...[more]