Ontology highlight
ABSTRACT:
SUBMITTER: Silva LA
PROVIDER: S-EPMC3434964 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Silva Laurie A LA Strang Blair L BL Lin Eric W EW Kamil Jeremy P JP Coen Donald M DM
Virology 20110723 2
The human cytomegalovirus DNA polymerase subunit UL44 is a phosphoprotein, but its sites and roles of phosphorylation have not been investigated. We compared sites of phosphorylation of UL44 in vitro by the viral protein kinase UL97 and cyclin-dependent kinase 1 with those in infected cells. Transient treatment of infected cells with a UL97 inhibitor greatly reduced labeling of two minor UL44 phosphopeptides. Viruses containing alanine substitutions of most UL44 residues that are phosphorylated ...[more]