Ontology highlight
ABSTRACT:
SUBMITTER: Trippa L
PROVIDER: S-EPMC3434985 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Trippa Lorenzo L Lee Eudocia Q EQ Wen Patrick Y PY Batchelor Tracy T TT Cloughesy Timothy T Parmigiani Giovanni G Alexander Brian M BM
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120529 26
<h4>Purpose</h4>To evaluate whether the use of Bayesian adaptive randomized (AR) designs in clinical trials for glioblastoma is feasible and would allow for more efficient trials.<h4>Patients and methods</h4>We generated an adaptive randomization procedure that was retrospectively applied to primary patient data from four separate phase II clinical trials in patients with recurrent glioblastoma. We then compared AR designs with more conventional trial designs by using realistic hypothetical scen ...[more]