Defining the conserved internal architecture of a protein kinase.
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ABSTRACT:
SUBMITTER: Kornev AP
PROVIDER: S-EPMC3435107 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Defining the conserved internal architecture of a protein kinase.
Kornev Alexandr P AP Taylor Susan S SS
Biochimica et biophysica acta 20091029 3
Protein kinases constitute a large protein family of important regulators in all eukaryotic cells. All of the protein kinases have a similar bilobal fold, and their key structural features have been well studied. However, the recent discovery of non-contiguous hydrophobic ensembles inside the protein kinase core shed new light on the internal organization of these molecules. Two hydrophobic "spines" traverse both lobes of the protein kinase molecule, providing a firm but flexible connection betw ...[more]
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