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Defining the conserved internal architecture of a protein kinase.


ABSTRACT: Protein kinases constitute a large protein family of important regulators in all eukaryotic cells. All of the protein kinases have a similar bilobal fold, and their key structural features have been well studied. However, the recent discovery of non-contiguous hydrophobic ensembles inside the protein kinase core shed new light on the internal organization of these molecules. Two hydrophobic "spines" traverse both lobes of the protein kinase molecule, providing a firm but flexible connection between its key elements. The spine model introduces a useful framework for analysis of intramolecular communications, molecular dynamics, and drug design.

SUBMITTER: Kornev AP 

PROVIDER: S-EPMC3435107 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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Defining the conserved internal architecture of a protein kinase.

Kornev Alexandr P AP   Taylor Susan S SS  

Biochimica et biophysica acta 20091029 3


Protein kinases constitute a large protein family of important regulators in all eukaryotic cells. All of the protein kinases have a similar bilobal fold, and their key structural features have been well studied. However, the recent discovery of non-contiguous hydrophobic ensembles inside the protein kinase core shed new light on the internal organization of these molecules. Two hydrophobic "spines" traverse both lobes of the protein kinase molecule, providing a firm but flexible connection betw  ...[more]

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