Dataset Information

Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease.

ABSTRACT:

Background

Health-related quality-of-life (HRQL) measures have been correlated with lung function in patients with COPD and interstitial lung disease (ILD). However, different pathophysiologic mechanisms may influence how these distinct diseases affect HRQL, resulting in differing HRQL by pulmonary diagnosis among patients with similar severity of ventilatory impairment.

Methods

The National Heart, Lung, and Blood Institute Lung Tissue Research Consortium provided data on well-characterized participants with COPD (n = 576) and ILD (n = 405) at four clinical sites. Using multiple linear regression, we examined the effects of FEV? (% predicted) and diagnosis (ILD vs COPD) on HRQL scores, including total St. George Respiratory Questionnaire (SGRQ) scores and Short Form-12 (SF-12) physical component summary (PCS) and mental component summary (MCS) scores.

Results

Participants with ILD had, on average, higher SGRQ scores (15.33 points; 95% CI, 12.46-18.19; P <.001) and lower SF-12 PCS scores (-4.73 points; 95% CI, -6.31 to -3.14; P <.001) compared with patients with COPD with similar FEV? % predicted values, indicating worse HRQL. The specific diagnosis also modified the effect of FEV? on the total SGRQ score (P = .003) and the SF-12 PCS score (P = .03). There was no relationship between lung function and SF-12 MCS scores.

Conclusions

HRQL scores were worse for patients with ILD compared with patients with COPD with similar degrees of ventilatory impairment. Differences in dyspnea mechanism or in the rate of disease progression may account for these differences in HRQL.

SUBMITTER: Berry CE

PROVIDER: S-EPMC3435139 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Publications

Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease.

Berry Cristine E CE Drummond M Bradley MB Han MeiLan K MK Li Daner D Fuller Cathy C Limper Andrew H AH Martinez Fernando J FJ Schwarz Marvin I MI Sciurba Frank C FC Wise Robert A RA

Chest 20120901 3

<h4>Background</h4>Health-related quality-of-life (HRQL) measures have been correlated with lung function in patients with COPD and interstitial lung disease (ILD). However, different pathophysiologic mechanisms may influence how these distinct diseases affect HRQL, resulting in differing HRQL by pulmonary diagnosis among patients with similar severity of ventilatory impairment.<h4>Methods</h4>The National Heart, Lung, and Blood Institute Lung Tissue Research Consortium provided data on well-cha ...[more]

PMID: 22576634

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Dataset Information

Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease.

Background

Methods

Results

Conclusions

Publications

Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease.

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