Ontology highlight
ABSTRACT:
SUBMITTER: Shaked H
PROVIDER: S-EPMC3435160 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Shaked Helena H Hofseth Lorne J LJ Chumanevich Alena A Chumanevich Alexander A AA Wang Jin J Wang Yinsheng Y Taniguchi Koji K Guma Monica M Shenouda Steve S Clevers Hans H Harris Curtis C CC Karin Michael M
Proceedings of the National Academy of Sciences of the United States of America 20120814 35
The role of NF-κB activation in tumor initiation has not been thoroughly investigated. We generated Ikkβ(EE)(IEC) transgenic mice expressing constitutively active IκB kinase β (IKKβ) in intestinal epithelial cells (IECs). Despite absence of destructive colonic inflammation, Ikkβ(EE)(IEC) mice developed intestinal tumors after a long latency. However, when crossed to mice with IEC-specific allelic deletion of the adenomatous polyposis coli (Apc) tumor suppressor locus, Ikkβ(EE)(IEC) mice exhibite ...[more]