Ontology highlight
ABSTRACT:
SUBMITTER: Bedke N
PROVIDER: S-EPMC3435262 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Bedke Nicole N Sammut David D Green Ben B Kehagia Valia V Dennison Patrick P Jenkins Gisli G Tatler Amanda A Howarth Peter H PH Holgate Stephen T ST Davies Donna E DE
PloS one 20120906 9
Rhinovirus (RV) infection is a major cause of asthma exacerbations which may be due to a deficient innate immune response in the bronchial epithelium. We hypothesized that the pleiotropic cytokine, TGF-β, influences interferon (IFN) production by primary bronchial epithelial cells (PBECs) following RV infection. Exogenous TGF-β(2) increased RV replication and decreased IFN protein secretion in response to RV or double-stranded RNA (dsRNA). Conversely, neutralizing TGF-β antibodies decreased RV r ...[more]