Ontology highlight
ABSTRACT:
SUBMITTER: Janiszewska M
PROVIDER: S-EPMC3435496 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Janiszewska Michalina M Suvà Mario L ML Riggi Nicolo N Houtkooper Riekelt H RH Auwerx Johan J Clément-Schatlo Virginie V Radovanovic Ivan I Rheinbay Esther E Provero Paolo P Stamenkovic Ivan I
Genes & development 20120816 17
Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for self-renewal, tumor initiation, and generation of nontumorigenic progeny. Despite their potentially key role in tumor establishment and maintenance, the energy requirements of these cells and the mechanisms that regulate their energy production are unknown. Here, we show that the oncofetal insulin-like growth factor ...[more]