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Biocatalytic production of tetrahydroisoquinolines.

ABSTRACT: The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet-Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.

SUBMITTER: Ruff BM 

PROVIDER: S-EPMC3435518 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Biocatalytic production of tetrahydroisoquinolines.

Ruff Bettina M BM   Bräse S S   O'Connor Sarah E SE  

Tetrahedron letters 20120201 9

The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet-Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids. ...[more]

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