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[1-Meth-oxy-3-(pyridin-2-yl)indolizin-2-yl](pyridin-2-yl)methanone.

ABSTRACT: Methyl-ation of [1-hy-droxy-3-(pyridin-2-yl)indolizin-2-yl](pyridin-2-yl)methanone was performed via metalation with potassium tert-butano-late in toluene and a subsequent metathesis reaction with methyl iodide yielded the yellow title compound, C(20)H(15)N(3)O(2). The substituents at the indolizine unit are twisted [the indolizine ring system makes dihedral angles of 34.67?(7) and 77.49?(5)°, respectively, with the pyridyl and pyridinoyl rings] with single bonds between the central unit and the attached pyridine ring [1.459?(3)?Å] and the pyridinoyl group [1.483?(3)?Å]. There are no classical hydrogen bonds in the crystal structure.

SUBMITTER: Kloubert T

PROVIDER: S-EPMC3435659 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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[1-Meth-oxy-3-(pyridin-2-yl)indolizin-2-yl](pyridin-2-yl)methanone.

Kloubert Tobias T Kretschmer Robert R Görls Helmar H Westerhausen Matthias M

Acta crystallographica. Section E, Structure reports online 20120804 Pt 9

Methyl-ation of [1-hy-droxy-3-(pyridin-2-yl)indolizin-2-yl](pyridin-2-yl)methanone was performed via metalation with potassium tert-butano-late in toluene and a subsequent metathesis reaction with methyl iodide yielded the yellow title compound, C(20)H(15)N(3)O(2). The substituents at the indolizine unit are twisted [the indolizine ring system makes dihedral angles of 34.67 (7) and 77.49 (5)°, respectively, with the pyridyl and pyridinoyl rings] with single bonds between the central unit and the ...[more]

PMID: 22969532

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