Ontology highlight
ABSTRACT:
SUBMITTER: Abate-Pella D
PROVIDER: S-EPMC3436068 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Abate-Pella Daniel D Zeliadt Nicholette A NA Ochocki Joshua D JD Warmka Janel K JK Dore Timothy M TM Blank David A DA Wattenberg Elizabeth V EV Distefano Mark D MD
Chembiochem : a European journal of chemical biology 20120411 7
The creation of caged molecules involves the attachment of protecting groups to biologically active compounds such as ligands, substrates and drugs that can be removed under specific conditions. Photoremovable caging groups are the most common due to their ability to be removed with high spatial and temporal resolution. Here, the synthesis and photochemistry of a caged inhibitor of protein farnesyltransferase is described. The inhibitor, FTI, was caged by alkylation of a critical thiol group wit ...[more]