Ontology highlight
ABSTRACT:
SUBMITTER: Geisler C
PROVIDER: S-EPMC3436151 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Geisler Christoph C Kotu Varshika V Sharrow Mary M Rendić Dubravko D Pöltl Gerald G Tiemeyer Michael M Wilson Iain B H IB Jarvis Donald L DL
The Journal of biological chemistry 20120628 35
Studying genetic disorders in model organisms can provide insights into heritable human diseases. The Drosophila neurally altered carbohydrate (nac) mutant is deficient for neural expression of the HRP epitope, which consists of N-glycans with core α1,3-linked fucose residues. Here, we show that a conserved serine residue in the Golgi GDP-fucose transporter (GFR) is substituted by leucine in nac(1) flies, which abolishes GDP-fucose transport in vivo and in vitro. This loss of function is due to ...[more]