Ontology highlight
ABSTRACT:
SUBMITTER: Prevette LE
PROVIDER: S-EPMC3436429 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Prevette Lisa E LE Nikolova Evgenia N EN Al-Hashimi Hashim M HM Banaszak Holl Mark M MM
Molecular pharmaceutics 20120820 9
The transfer of genetic material into cells using nonviral vectors offers unique potential for therapeutics; however, the efficacy of delivery depends upon a poorly understood, multistep pathway, limiting the prospects for successful gene delivery. Mechanistic insight into DNA association and release has been hampered by a lack of atomic resolution structural and dynamic information for DNA-polymer complexes (polyplexes). Here, we report a dendrimer-based polyplex system containing poly(ethylene ...[more]